Tuscany and Lazio by motorhome
Pisa, wine country, cypress hills and a village on a crumbling rock. Ends in Rome, so plan for the ZTL.
- Distance
- 349 km (217 mi)
- Driving
- 4 h 49 min
- Suggested days
- 5
- Stops
- 8
- Countries
- Italy
- Updated
- September 20, 2026
At a glance: 5-day road trip of about 349 km (217 mi) with 8 stops, from Pisa to Rome. About 4 h 49 min of driving in total.
Route description
Start in Pisa at the Piazza dei Miracoli, where the leaning tower, cathedral and baptistery stand on a lawn; book tower climbs ahead in summer. Then head inland to Siena, whose shell-shaped Piazza del Campo hosts the Palio horse race each July and August.
South of Siena, follow the SR2 Via Cassia through the Crete Senesi to Montalcino, a hill town famous for Brunello wine. A farm stopover near Montalcino is a quiet place to spend the night among the vineyards, and there is also a farm campsite near San Quirico d’Orcia.
The Val d’Orcia around San Quirico is a UNESCO landscape of rolling hills lined with cypresses, and the best-known cypress group stands right beside the SR2. Continue south on the Via Cassia past Lake Bolsena to Civita di Bagnoregio, a hilltop village on crumbling clay, reached only by a steep footbridge; there is an entry fee.
The route ends in Rome. Most Italian historic centres, including Siena and Rome, are ZTL limited traffic zones monitored by cameras, and entering without a permit leads to fines, so stay at a campsite on the edge of Rome and use public transport into the city.
Stop-by-stop itinerary
In driving order. Distances are estimates between consecutive stops.
- 1Start
Pisa
Italy - 21 km
Piazza dei Miracoli
HistoryPisa, ItalyThe leaning tower, cathedral and baptistery on a lawn. Book tower climbs ahead in summer.
- 3110 km
Piazza del Campo
HistorySiena, ItalyA shell-shaped medieval square that hosts the Palio horse race each July and August.
- 440 km
Montalcino
Italy - 511 km
Farm campsite, San Quirico d'Orcia
CampingSan Quirico d'Orcia, Italy - 61 km
Val d'Orcia cypresses
ViewsSan Quirico d’Orcia, ItalyRolling Tuscan hills lined with cypresses, a UNESCO landscape. The best-known cypress group is beside the SR2.
- 779 km
Civita di Bagnoregio
OdditiesBagnoregio, ItalyA hilltop village on crumbling clay, reached only by a steep footbridge. There is an entry fee.
- 8108 km
Rome
Italy