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E45

Sicily loop: temples, Etna and Baroque towns

From Palermo along the north coast to Etna and Taormina, then south through the Baroque towns to the Valley of the Temples.

Distance
674 km (419 mi)
Driving
9 h 18 min
Suggested days
7
Stops
10
Countries
Italy
Updated
September 20, 2026

At a glance: 7-day round trip of about 674 km (419 mi) with 10 stops, starting and ending in Palermo. About 9 h 18 min of driving in total.

Route description

From Palermo, the A20 motorway, which has tolls, follows the north coast east to Cefalù, a seaside town with a Norman cathedral below a huge rock. Continue east and then south to the flanks of Etna.

Europe’s most active volcano can be approached by road from Nicolosi to Rifugio Sapienza at about 1,900 m; from there, take the cable car or walk among old craters. Access to the higher slopes depends on volcanic activity, so check the current situation locally. Taormina, on a terrace above the sea, has a Greek theatre with views of Etna; the town has limited traffic, so use the car parks below.

Further south, Syracuse has a Greek theatre and the old town on the island of Ortigia. The route then turns inland to Noto, rebuilt in honey-coloured Baroque after the 1693 earthquake; climb the cathedral steps at dusk. Ragusa, with its old quarter of Ibla on a ridge, is another of the Baroque towns of the Val di Noto.

On the south coast, the Valle dei Templi at Agrigento is a ridge of Greek temples among almond and olive trees, among the best preserved outside Greece. Just west, the Scala dei Turchi, a white marl cliff, steps down into the sea; go late in the day, when it glows against the blue water. The road back to Palermo crosses the interior, and summer heat makes early starts sensible.

Stop-by-stop itinerary

In driving order. Distances are estimates between consecutive stops.

  1. 1

    Palermo

    Italy
    Start
  2. 2

    Cefalù

    Italy
    73 km
  3. 3

    Etna – Rifugio Sapienza

    NatureNicolosi, Italy

    Europe’s most active volcano. Drive to about 1,900 m, then take the cable car or walk among old craters.

    117 km
  4. 4

    Taormina

    Italy
    38 km
  5. 5

    Syracuse

    Italy
    108 km
  6. 6

    Noto Cathedral

    HistoryNoto, Italy

    The centrepiece of a town rebuilt in honey-coloured Baroque after the 1693 earthquake. Climb the steps at dusk.

    35 km
  7. 7

    Ragusa

    Italy
    39 km
  8. 8

    Valle dei Templi

    HistoryAgrigento, Italy

    A ridge of Greek temples among almond and olive trees, among the best preserved outside Greece.

    136 km
  9. 9

    Scala dei Turchi

    NatureRealmonte, Italy

    A white marl cliff that steps down into the sea like a staircase. Go late in the day, when it glows against the blue water.

    12 km
  10. 10

    Palermo

    Italy
    115 km